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Dr. Engle is a child neurologist and developmental neurogeneticist who seminal research has defined a new category of developmental brain disorder manifesting as congenital ocular or facial dysmotility, and often accompanied by motor and cognitive dysfunction as well as non-neurological birth defects. She received her M.D. from Johns Hopkins University School of Medicine, trained in pediatrics at Johns Hopkins, in neuropathology at Massachusetts General Hospital, and in adult and child neurology in the Longwood Neurology Training Program and Boston Children’s Hospital. Nearing the end of her neurology residency, Dr. Engle cared for a toddler born with a complex eye movement disorder that segregated in his family as a dominant trait. Interested in the etiology of his rare disorder, she pursued a research fellowship in genetics. As a result, this little boy became the proband for Dr. Engle’s research career, which now spans from patients through genetics to molecular mechanisms in order to understand normal and abnormal cranial motor neuron and axon development. Her work has been recognized by high-profile publications and by receipt of multiple honors, including election to the National Academy of Medicine.